Xiaoping Gu Selected Research

Cognitive Dysfunction

3/2024	Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance.
1/2024	Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.
11/2023	Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction.
1/2023	IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders.
12/2022	Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment.
11/2022	Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice.
8/2022	Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice.
3/2022	Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice.
1/2022	The role of 5-HT7R in the memory impairment of mice induced by long-term isoflurane anesthesia.
1/2021	Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice.

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Xiaoping Gu Research Topics

Disease

50	Pain (Aches) 05/2024 - 10/2007
42	Hyperalgesia 05/2024 - 10/2007
18	Cognitive Dysfunction 03/2024 - 01/2012
17	Bone Neoplasms (Bone Cancer) 01/2023 - 10/2010
16	Neuralgia (Stump Neuralgia) 03/2024 - 10/2010
16	Neoplasms (Cancer) 01/2024 - 01/2004
16	Postoperative Pain 10/2023 - 12/2009
10	Neuroinflammatory Diseases 05/2024 - 01/2012
8	Postoperative Cognitive Complications 01/2024 - 01/2012
8	Chronic Pain 12/2023 - 07/2014
6	Inflammation (Inflammations) 04/2020 - 08/2011
5	Breast Neoplasms (Breast Cancer) 01/2023 - 10/2007
5	Hypersensitivity (Allergy) 01/2022 - 01/2017
4	Mitochondrial Diseases (Mitochondrial Disease) 03/2024 - 10/2021
4	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2023 - 01/2016
4	Ischemia 10/2021 - 01/2012
4	Surgical Wound 03/2017 - 09/2014
4	Cancer Pain 09/2014 - 08/2011
3	Neuroblastoma 03/2024 - 01/2021
3	Neurocognitive Disorders (Clerambault Syndrome) 03/2024 - 12/2022
3	Memory Disorders (Memory Loss) 11/2022 - 01/2018
3	Infections 08/2022 - 06/2011
3	Osteosarcoma (Osteogenic Sarcoma) 01/2018 - 07/2012
3	Melanoma (Melanoma, Malignant) 06/2010 - 10/2007
2	Emergence Delirium 03/2024 - 01/2022
2	Necrosis 12/2023 - 12/2016
2	Cough 10/2023 - 01/2023
2	Delirium 08/2022 - 01/2022
2	Tibial Fractures (Fracture, Tibial) 01/2022 - 03/2019
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2020
2	Insulin Resistance 01/2021 - 01/2020
2	Hyperglycemia 01/2021 - 01/2020
2	Postoperative Nausea and Vomiting (PONV) 03/2020 - 09/2017
2	Liver Neoplasms (Liver Cancer) 08/2019 - 01/2019

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 03/2024 - 01/2012
15	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2016 - 01/2008
14	Isoflurane FDA LinkGeneric 01/2024 - 03/2016
12	Remifentanil (Ultiva)FDA Link 05/2024 - 12/2009
12	CytokinesIBA 01/2022 - 12/2008
11	Analgesics (Analgesic Drugs)IBA 01/2023 - 11/2013
8	Messenger RNA (mRNA)IBA 11/2023 - 10/2007
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 10/2007
6	Estrogen ReceptorsIBA 01/2023 - 05/2015
6	Interleukin-6 (Interleukin 6)IBA 03/2022 - 01/2012
6	salicylhydroxamic acid (SHAM)IBA 01/2018 - 10/2010
5	Biomarkers (Surrogate Marker)IBA 03/2024 - 04/2015
5	Anesthetics (Anesthetic Agents)IBA 10/2023 - 01/2015
5	Cannabinoid Receptors (Cannabinoid Receptor)IBA 10/2020 - 08/2011
5	N-Methylaspartate (NMDA)IBA 01/2019 - 12/2009
4	Opioid Analgesics (Opioids)IBA 01/2023 - 12/2009
4	Antisense OligonucleotidesIBA 11/2020 - 07/2013
4	Dexmedetomidine FDA Link 03/2020 - 08/2017
4	InterleukinsIBA 01/2020 - 04/2015
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2019 - 09/2014
4	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2017 - 01/2015
3	Minocycline (Cyclops)FDA LinkGeneric 01/2024 - 01/2016
3	EsketamineIBA 01/2024 - 01/2022
3	General AnestheticsIBA 08/2022 - 01/2021
3	Phosphotransferases (Kinase)IBA 01/2020 - 07/2014
3	Ketamine FDA LinkGeneric 01/2020 - 12/2009
3	N- (1- azabicyclo(2.2.2)oct- 3- yl)furo(2,3- c)pyridine- 5- carboxamideIBA 01/2019 - 01/2015
3	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 01/2019 - 01/2015
3	CB2 Cannabinoid ReceptorIBA 01/2017 - 08/2011
3	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2017 - 07/2013
3	RoscovitineIBA 09/2014 - 07/2012
3	NR2B NMDA receptorIBA 11/2013 - 12/2009
2	Glucose (Dextrose)FDA LinkGeneric 05/2024 - 01/2021
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2024 - 01/2015
2	Eosine Yellowish-(YS) (Eosin)IBA 01/2024 - 04/2020
2	Hematoxylin (Haematoxylon)IBA 01/2024 - 04/2020
2	Sirtuin 1IBA 01/2024 - 01/2022
2	Tight Junction ProteinsIBA 11/2023 - 04/2020
2	Ropivacaine (Naropin)FDA LinkGeneric 10/2023 - 09/2017
2	RNA (Ribonucleic Acid)IBA 05/2023 - 01/2016
2	EnzymesIBA 01/2023 - 12/2020
2	Connexin 43 (Connexin43)IBA 12/2022 - 03/2022
2	LipopolysaccharidesIBA 11/2022 - 01/2020
2	Metformin (Glucophage)FDA LinkGeneric 08/2022 - 01/2021
2	Saline SolutionIBA 01/2022 - 09/2017
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2018
2	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2016
2	Insulin (Novolin)FDA Link 01/2021 - 01/2020
2	Pioglitazone (Actos)FDA Link 11/2020 - 04/2020
2	GTP-Binding Proteins (G-Protein)IBA 07/2020 - 01/2020
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 07/2020 - 03/2017
2	Cysteine (L-Cysteine)FDA Link 07/2020 - 03/2017
2	Dexamethasone (Maxidex)FDA LinkGeneric 03/2020 - 06/2014
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 08/2019 - 01/2019
2	RNA Splicing FactorsIBA 01/2019 - 05/2015
2	Phenobarbital (Luminal)FDA Link 01/2018 - 05/2015
2	MelatoninIBA 01/2018 - 03/2016

Therapy/Procedure

20	Anesthesia 03/2024 - 03/2016
16	Spinal Injections 03/2024 - 01/2012
15	Therapeutics 12/2023 - 10/2010
5	General Anesthesia 01/2024 - 01/2015
4	Analgesia 03/2022 - 08/2011
4	Intraperitoneal Injections 07/2020 - 10/2010
2	Hip Replacement Arthroplasty (Total Hip Replacement) 04/2024 - 01/2023
2	Perioperative Period 01/2023 - 01/2019
2	Length of Stay 08/2022 - 03/2020